Professor Prakash Ramchandran  is Professor of Experimental Hepatology and  an MRC Senior Clinical Fellow at the University of Edinburugh (U.K.). He is also an Honorary Consultant Hepatologist at the Royal Infirmary of Edinburgh and Scottish Liver Transplant Unit. His research is focused on understanding the cellular and molecular mechanisms of fibrosis in the liver, how these are conserved between organs and how they might be targeted therapeutically. To address this, his lab employs cutting-edge -omics techniques on human samples (including single-cell RNA-seq, spatial transcriptomics and high-dimensional imaging).

A key focus of his lab is the role of inflammation in regulating liver injury and fibrosis. He recently defined a novel population of pathogenic macrophages in the fibrotic niche of fibrotic human liver tissue (Nature, 2019) and are now actively working to identify approaches to selectively inhibit the function of these macrophages and reduce tissue scarring in metabolic and other liver diseases.